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Nobil Bio Ricerche philosophy is to think at implant devices surfaces as the contact point between two Worlds that need to communicate. For this reason, we research and work to develop a common language, that would allow information exchange between implant devices materials and cells&tissues that host them in the body. Roughness, chemical composition, surface immobilization of specific molecules, drug-release, become the tools used by the device to communicate with the basic component of the host tissue, the cells, and to direct their behavior: implant devices surfaces as an active interface with cells is the key-philosophy of Nobil Bio Ricerche, a philosophy that overtakes the classical inert and mechanical approach and calls into action new biotechnological knowledge applied to materials. This vision is implemented in the surface treatment and packaging of dental implants, through approaches aimed at cell stimulation and prevention of unwanted side-effects, by careful chemical and biological cleaning of implant; through the development of innovative treatment and materials, based on the control of interfacial cell behavior; through a continuous research activity on the cell-implant interface, backed by in-house specific analytical and in vitro facilities Nobil Bio Ricerche goal is to play as an active and driving force in the biotechnological revolution of implant devices
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News
8 July 2011
Project SCATE begins: Scaffolds for tissue engineering.
Whithin the framework of the MATERA program, debuts the SCATE project : Scaffolds for Tissue Engineering, headed by the Finnish University of Oulu. Nobil Bio Ricerche is a partner of the project, whose details can be found at http://www.scate.oulu.fi/
12 September 2011
Nobil Bio Ricerche at the meeting of the Societa’ Italiana di OrtopediaNobil Bio Ricerche will present three scientific communcations at the forthcoming meeting of the Societa’ Italiana di Ortopedia, to be held in Rimini in the first week of October http://www.congressosiot.it-2011. Communcations discuss results of surface analysis of orthopedic devices and of research activity on implant devices surface-modified by biomolecules
14 September 2011
Nobil Bio Ricerche at Life-Med 2011
Nobil Bio Ricerche will attend to Life-Med 2011, the International Life Sciences Event, on October 6th, in Milan, by presenting a communication titled: “Engineering tissue response by biochemical modification of implant materials surfaces” in the session on Tissue Engineering and Biomaterials
20 October 2011
New document in the download section
A new document is available in the download section of this web site. It describes the use of gene expression techniques for the development of novel implant materials. By this document, together with more documents that will be available shortly, Nobil Bio Ricerche underlines the role of biotechnology techniques for the development of innovative materials and describes the tools that are at the basis of the quality of its services
13 December 2011
New analytical work available in the dowload section
The document “VALUTAZIONE DEL RAPPORTO TRA COSTO E QUALITA’ DELLA PULIZIA SUPERFICIALE DI ALCUNI SISTEMI IMPLANTARI IN COMMERCIO” is available in the download section. This work, part of a ongoing cooperation with Dr. Marco Bellanda, tries to answer to basic questions Dentists make when considering products that are offered on the market. This is particulary important in the present economic struggle, that requires care in cost management, without imparing quality and reliability. This work underlines also the merits of the application of surface analysis and biotechnology techniques in the evaluation of dental implant surfaces. Nobil Bio Ricerche is among the few companies that routinously adopt these techniques for the evaluation of its own surface treatment activity, providing a product quality in tune with the most advanced and sophisticated approaches. This quality is made available to our customers
Our services
Treatments
Recent publications
Gene expression of markers of osteogenic differentiation of human mesenchymal cells on collagen I-modified microrough titanium surfaces.
Morra M, Cassinelli C, Cascardo G, Bollati D, Baena RR.
J Biomed Mater Res A. 2011 Feb;96(2):449-55.
Multifunctional implant surfaces: surface characterization and bone response to acid-etched Ti implants surface-modified by fibrillar collagen I.
Morra M, Cassinelli C, Cascardo G, Bollati D, Rodriguez Y Baena R.
J Biomed Mater Res A. 2010 Jul;94(1):271-9.
Pectin-coated titanium implants are well-tolerated in vivo.
Kokkonen H, Niiranen H, Schols HA, Morra M, Stenbäck F, Tuukkanen J.
J Biomed Mater Res A. 2010 Jun 15;93(4):1404-9
Inhibition of LPS-induced proinflammatory responses of J774.2 macrophages by immobilized enzymatically tailored pectins.
Gallet M, Vayssade M, Morra M, Verhoef R, Perrone S, Cascardo G, Vigneron P, Schols HA, Nagel MD.
Acta Biomater. 2009 Sep;5(7):2618-22.
Development of the osteoblastic phenotype in human alveolar bone-derived cells grown on a collagen type I-coated titanium surface.
de Assis AF, Beloti MM, Crippa GE, de Oliveira PT, Morra M, Rosa AL.
Clin Oral Implants Res. 2009 Mar;20(3):240-6.
Covalently-linked hyaluronan promotes bone formation around Ti implants in a rabbit model.
Morra M, Cassinelli C, Cascardo G, Fini M, Giavaresi G, Giardino R.
J Orthop Res. 2009 May;27(5):657-63
Differentiation of osteoblasts on pectin-coated titanium.
Kokkonen H, Cassinelli C, Verhoef R, Morra M, Schols HA, Tuukkanen J.
Biomacromolecules. 2008 Sep;9(9):2369-76.